FORMULATION AND EVALUATION OF INDOMETHACIN MICROSPHERES FOR COLONIC DRUG DELIVERY SYSTEM Kulkarni P Keshavarao*, Dixit Mudit, Panner Selvam and Singh D Rudra

Colon specific drug delivery has gained increased importance not just for delivery of drug for the treatment of local diseases, associated with the colon but also potential site for systemic delivery of therapeutic drug. Indomethacin is non‐steroidal anti‐inflammatory drug with short half life. Indomethacin Microspheres were prepared by solvent evaporation method using Eudragit L‐100 and Eudragit S‐100 mixture [1:2, 1:3, 1:4, and 1:5] were used as pH‐sensitive polymers. The prepared Microspheres were evaluated for various physicochemical parameters such as particle size, percentage yield, incorporation efficiency, drug polymer compatibility (IR study), scanning electron microscopy (SCM) and drug release of Microsphere (pH 6.8) for 12 hrs. Result shows that as the concentration of polymer increases it affects the particle size, percentage yield and drug release of micro capsules. The flow properties were found to be good and scanning electron microscopy confirmed their hollow structure with smooth surface. Formulation F1 shows excellent particle size, percentage yield (90.24%), incorporation efficiency (95.59%) and percentage drug release (95.58%) for a period of 12 hrs. Results of our present study suggest that Indomethacin Microspheres can be successfully designed to develop sustained drug delivery, which can improve compliance by reducing dosing frequency.